Living, dining, family and bed rooms.  For busy ladies that are looking for simplicity, this rule is key-LESS IS MORE.  The fewer items you have in each room, the fewer things that need cleaned and cared for.  Not to mention, believe it or not, it really does make a difference in how you feel mentally! 

Instead of having 10 little flower vases on your coffee table, opt for one large and beautiful floral arrangement.  If you have a small section on your kitchen counter edge that is sort of your "collect all"-mail, loose change, cough drops, etc.-get a nice sized and attractive basket to set there, and drop your loose belongings in it until you get around to needing them or putting them away. 

Don't have too many hobbies, or things you collect.  Too many hobbies usually result in very little of any of them getting the attention you want to give them.  Pick your one or two favorites, and pass on the rest.  Collections can be pretty, but if you have to dust them regularly, and you they're more hassle than you really feel they're worth, get rid of them.

If you want something new for your decor, and have $30 to spend, buy one large item, instead of 15 small items.  Less clutter for you, a bolder decorative statement, and easier to care for.

When you have fewer items sitting around, it is much easier and quicker to dust, and much easier to vaccuum.  I do not have a set day that I clean my house.  I only work outside the home part time, so I do things throughout most days.  If I have a lot of company over, I will vaccuum after they leave.  While visiting, I'll load the dishwasher and run it.  Our home doesn't look like a museum-we use ALL of it.  I don't look for perfection in cleaning, but try to keep things presentable.  I don't have a lot of knick knacks, so it doesn't take long to get things looking decent.  I also like to spend a few minutes straightening up before I go to bed, so that I have a cleaner home to face in the morning while getting the kiddos ready for school.  The kitchen is actually the room I feel is most important for a little before-bed straightening.  It is much easier to get breakfasts, pack lunches and make coffee when the countertops are cleared of any dirty dishes and clutter.

Don't hang on to 12 years worth of women's magazines.  Medical science and technology have changed drastically, fashions have changed, and those old recipe pictures never look as appealing as the newer, clearer pictures.

I personally don't like to hang on to very many books after I've read them either.  I either pass them on, throw them away(if they're what I consider junk), or only occasionally keep them if I find them exceptional, and something I want to re-read.